IGF1-DES 2mg – Insulin-like Growth Factor 1 DES(1-3) from Myotrope

IGF-1 DES (1-3) is a truncated version of Insulin-like Growth Factor 1, designed for local tissue research and preclinical applications. Its unique structure gives it increased receptor affinity and potent anabolic activity in specific tissues, making it ideal for studies of muscle growth, satellite cell activation, and connective tissue regeneration in controlled laboratory conditions.

What is Myotrope's IGF1-DES?

IGF-1 DES is a shortened form of IGF-1 with the first three N-terminal amino acids removed (DES(1-3)). This results in the following properties:

• Short half-life (~20–30 minutes) – suitable for site-specific effects
• High receptor affinity – up to 10x more potent locally than native IGF-1
• Reduced binding to IGF-binding proteins – increases availability in target tissue

This makes IGF-1 DES suitable for research into:

• Muscle hypertrophy and hyperplasia
• Activation of satellite cells and muscle stem cells
• Regeneration of tendons, ligaments and connective tissue
• Local anabolic signaling (mTOR, PI3K/Akt)
  

How does IGF1-DES work?

IGF-1 DES selectively binds to IGF-1 receptors in target tissues, activating cellular responses:

1. Enhances local anabolic signal – stimulates protein synthesis and muscle growth
2. Satellite cell activation – supports myogenesis and tissue regeneration
3. Stimulation of collagen and fibroblasts – useful for connective tissue research
4. Modulation of nutrient uptake – increases glucose and amino acid uptake into target tissues

This makes IGF-1 DES particularly valuable in preclinical studies focused on local hypertrophy and repair mechanisms.

IGF-1 DES is often used for:

• Research into local muscle growth and hypertrophy signals
• Study of satellite cell activation and hyperplasia
• Research into the recovery of tendons, ligaments and connective tissue
• Preclinical evaluation of growth factor signaling pathways
• Analysis of peptide combinations such as BPC-157, TB500 and GH secretagogues