Retatrutide – Onderzoek naar afvallen, vetverlies & metabolisme

Retatrutide – Weight Loss, Fat Loss & Metabolism Research

What is Retatrutide?

Retatrutide is an investigational peptide that acts as a triple agonist for GLP-1R, GIPR, and GCGR.
It is used in laboratory studies to study the following processes:

  • Weight loss and reduction of body fat
  • Regulation of appetite and satiety
  • Energy expenditure and fat oxidation
  • Improving glycemic control and insulin sensitivity

How does Retatrutide work according to research?

Retatrutide activates multiple hormone receptors simultaneously:

  • GLP‑1R: stimulates insulin release, delays stomach emptying and reduces appetite → helps with weight loss.
  • GIPR: enhances insulin response and supports fat metabolism → contributes to fat loss.
  • GCGR (glucagon receptor): increases energy expenditure and fat oxidation → supports both weight loss and fat loss.

This combined action makes Retatrutide interesting for research into obesity, metabolic disorders, weight loss and fat loss.

Research results and applications

  • Phase 2 clinical studies show average weight loss of up to ~24% in 48 weeks .
  • Improved insulin sensitivity and metabolic markers were observed.
  • Retatrutide is being studied for weight loss, body fat reduction, appetite regulation, and improving metabolic flexibility.

Importance of purity and quality

For reliable research results, it is essential that Retatrutide samples meet high purity criteria by HPLC analysis and COA documentation (≥98% or ≥99%).

How do you store Retatrutide?

  • Store as freeze-dried powder (lyophilisate) below -20 °C .
  • After reconstitution, store refrigerated (2-8 °C) for a short period.
  • Protect from light and moisture to maintain stability and reproducibility.

Why researchers choose Retatrutide

Researchers choose Retatrutide because:

  • Triple agonistic activity (GLP-1 + GIP + glucagon)
  • Effects on weight loss, fat loss, and metabolic health
  • Reproducible models for energy, insulin, and body weight studies

Conclusion

Retatrutide is an advanced research peptide with promising results for weight loss, fat loss, and energy expenditure . Researchers focusing on obesity, insulin resistance, or body composition may find this peptide valuable.

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