PE-22-28 Peptide – Peptide for Neuroprotection and Stress

How does PE-22-28 work?

PE-22-28 simulates part of galanin and affects the receptor systems in the brain and nervous system:

Receptor targeting

• Interaction with receptors that regulate mood, memory and pain perception
• Possible effects on stress resistance, anxiety reduction and cognitive performance

Neuroprotection

• Supports neurons by reducing excitatory stress and maintaining mitochondrial stability
• May help neurons function effectively under oxidative or nutritional stress

Pain modulation

• Research focus: Reduction of excessive pain signals without the risk of dependence as with opioids

Cognition & Emotional Regulation

• Influence on neurotransmitters such as serotonin, dopamine and norepinephrine
• Possible improvement in focus, memory and stress adaptation

Potential benefits of PE-22-28

Stress Resistance & Mood Support

• Neurotransmitter balance for greater calmness and improved stress response
• Research models show reduced anxiety-like behaviors
• Promotes stress adaptation during high workloads or intensive training

Cognitive performance & memory

• Supports neuroplasticity
• Protects neurons against excitatory stress
• Can improve focus and attention

Pain modulation

• Influences nociceptive pathways without risk of dependence
• Possible lowering effects on neural inflammation

Neuroprotection & Longevity

• Supports mitochondrial function in neurons
• Protection against oxidative damage
• Research suggests potential anti-aging benefits for the nervous system

Preclinical Research & Dosing

PE-22-28 is still in preclinical development , mostly in rodents:

• Doses: micrograms per kilogram (µg/kg)
• Administration: subcutaneous or intraperitoneal; intranasal routes investigated
• Cycle length: short, focused study periods, no chronic administration
• Results: improved stress adaptation, memory support, neuroprotection

Safety & Side Effects

• Tolerance: Preclinical studies generally show good tolerance
• Central effects: may influence mood, motivation and pain response
• Sleep & arousal: can cause relaxation or temporary drowsiness
• Appetite & gastrointestinal: minor changes in appetite possible
• Cardiometabolic: indirect effects on heart rate, blood pressure and glucose possible

⚠️Important : Without human studies, long-term effects and interactions remain unknown. PE-22-28 remains suitable for controlled laboratory studies only .

PE-22-28 versus other peptides

Peptide	Focus	Effects	Use-case framing
Selank	Anxiety & mood	Calming, mild cognitive	Daily regulator
Semax	Cognition & neuroprotection	Focus, blood supply to the brain	Productivity and concentration
Epitalon	Anti-aging	Sleep, telomeres, lifespan	Long-term health
BPC-157	Restore tissue	Intestine, tendons, muscles	Body recovery
PE-22-28	Stress, mood, cognitive	Neuroprotection, stress resistance, pain modulation	Targeted tuning of the nervous system

PE-22-28 is a promising peptide fragment that further simplifies the potent effects of galanin for stress management, neuroprotection, pain modulation, and cognitive functions .

⚗️ For researchers and laboratories: PE-22-28 offers a precise tool to study and optimize the nervous system, without the “extra effects” of full galanin.